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KMID : 0374920050260010141
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Inje Medical Journal
2005 Volume.26 No. 1 p.141 ~ p.147
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Acute renal failure,Membranous Nephropathy;Hepatitis in Secondary Syphilis
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Kim Hyun-Su
Park Young-Jung
Um Heung-Sik
Choi Sang-Bong
Lee Hwal-Youn
Kim Sang-Hyun
Park Won-Do
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Abstract
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Syphilis is a systemic infectious disease infected by the spirochete Treponema pallidum. It shows variable clinical manifestations. Nephrotic syndrome from secondary syphilis is a rare complication in Korea. One letter was reported before in Korea. This report describes 64-year-old male patient with syphilis presented with feature of hepatitis, acute renal failure and nephrotic syndrome.
A diagnosis of secondary syphilis was done by the serologic test for syphilis. After diagnosis of syphilis, we supposed that nephrotic syndrome and hepatitis were the complication of secondary syphilis and performed a kidney biopsy. A kidney biopsy revealed membranous nephropathy characterized by subepithelial deposits involving the glomerular basement membrane and effacement of epithelial foot-process on electron microscopy. The patient was treated with intramuscular benzathine penicillin 2.4 million units. Proteinuria, renal failure, hepatitis were resolved in 3 weeks after penicillin therapy.
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